SCALING METHOD FOR FAST MONTE CARLO SIMULATION OF DIFFUSE REFLECTANCE SPECTRA FROM MULTI-LAYERED TURBID MEDIA AND METHODS AND SYSTEMS FOR USING SAME TO DETERMINE OPTICAL PROPERTIES OF MULTI-LAYERED TURBID MEDIUM FROM MEASURED DIFFUSE REFLECTANCE

摘要

The presently disclosed subject matter relates to multilayered scaling methods that allow for implementation of fast Monte Carlo simulations of diffuse reflectance from multilayered turbid media. The disclosed methods employ photon trajectory information provided by only a single baseline simulation, from which the diffuse reflectance can be computed for a wide range of optical properties in a multilayered turbid medium. A convolution scheme is also incorporated to calculate diffuse reflectance for specific fiber-optic probe geometries. Also provided are systems for fast Monte Carlo simulation of diffuse reflectance of a multilayered turbid medium to rapidly determine diffuse reflectance for the multilayered turbid medium with known optical properties and for using the scaled diffuse reflectance to determine optical properties of a turbid medium having unknown optical properties.