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跨壁复极离散度

跨壁复极离散度的相关文献在2003年到2019年内共计58篇,主要集中在内科学、基础医学、药学 等领域,其中期刊论文58篇、专利文献345034篇;相关期刊37种,包括环球中医药、现代中西医结合杂志、中国中医药现代远程教育等; 跨壁复极离散度的相关文献由178位作者贡献,包括崔长琮、吴尚勤、姚青海等。

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跨壁复极离散度—发文趋势图

跨壁复极离散度

-研究学者

  • 崔长琮
  • 吴尚勤
  • 姚青海
  • 孙姗
  • 张玲玮
  • 江力勤
  • 王东琦
  • 蒋芬芬
  • 于忠祥
  • 张建勤
  • 期刊论文
  • 专利文献

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    • 王静; 高敏; 郑安然
    • 摘要: 目的:探讨心电图Tp-Tec,QTc,Tp-Te/QT比值对AMI患者急性期发生室性心律失常的诊断价值.方法:回顾性分析2014年10月至2017年10月就诊中国科学技术大学附属第一医院的186例AMI患者心电图,按急性期是否发生室性心动过速和/或心室颤动分为室性心律失常组(观察组,n=106)和无室性心律失常组(对照组,n=80),测量所有患者病程在24 h内的第1份(急性期)心电图及出院时(恢复期)心电图,对入组人群的Tp-Tec,QTc,Tp-Te/QT比值进行分析.结果:两组恢复期Tp-Tec,QTc和Tp-Te/QT比值明显低于急性期,差异均有统计学意义(P<0.05);与对照组相比,观察组急性期Tp-Tec,QTc和Tp-Te/QT比值明显升高,差异均有统计学意义(P<0.05),而恢复期两组间心电指标差异无统计学意义(P>0.05).Tp-Tec,Tc和Tp-Te/QT与急性期室性心律失常的发生呈正相关(分别r=0.761,P=0.015;r=0.823,P=0.039;r=0.156,P<0.001).ROC曲线分析Tp-Tec,QTc和Tp-Te/QT对AMI患者室性心律失常发生的预测价值,结果表明以Tp-Tec作为急性期室性心律失常发生的预测指标,最佳临界值为125.26 ms,ROC曲线下面积为0.9218,具有较高的诊断价值;以QTc作为预测指标,最佳临界值为433.32 ms,ROC曲线下面积为0.8231,诊断价值中等;以Tp-Te/QT比值作为预测指标,最佳临界值为0.29,ROC曲线下面积为0.9608,诊断价值最高.结论:Tp-Tec,QTc,Tp-Te/QT与AMI患者急性期室性心律失常的发生存在明显正相关,对于室性心律失常的发生均具有预测价值,同时Tp-Tec,QTc及Tp-Te/QT有助于评价AMI患者的预后.
    • Zhang Li; Liu Tong
    • 摘要: J波主要是因心室外膜复极1相Ito电流相对增大,使心室肌内外膜之间产生电位差引起J点上移而形成的圆顶形心电波.高危J波与恶性心律失常密切相关,是心脏性猝死的高危预警信号.%The J wave is a J-point elevation generated dome-shaped ECG phenomenon, which is caused by the potential difference between the endocardium and epicardium of ventricle that mediated by the relatively large Ito in epicardial phase 1 repolarization. The presence of high-risk J wave and it-mediated phase 2 reentry is closely associated to malignant arrhythmia and is an early warning sign for sudden cardiac death.
    • 王静1; 高敏1; 郑安然1
    • 摘要: 目的:探讨心电图Tp-Tec,QTc,Tp-Te/QT比值对AMI患者急性期发生室性心律失常的诊断价值。方法:回顾性分析2014年10月至2017年10月就诊中国科学技术大学附属第一医院的186例AMI患者心电图,按急性期是否发生室性心动过速和/或心室颤动分为室性心律失常组(观察组,n=106)和无室性心律失常组(对照组,n=80),测量所有患者病程在24h内的第1份(急性期)心电图及出院时(恢复期)心电图,对入组人群的Tp-Tec,QTc,Tp-Te/QT比值进行分析。结果:两组恢复期Tp-Tec,QTc和Tp-Te/QT比值明显低于急性期,差异均有统计学意义(P0.05)。Tp-Tec,QTc和Tp-Te/QT与急性期室性心律失常的发生呈正相关(分别r=0.761,P=0.015;r=0.823,P=0.039;r=0.156,P<0.001)。ROC曲线分析Tp-Tec,QTc和Tp-Te/QT对AMI患者室性心律失常发生的预测价值,结果表明以Tp-Tec作为急性期室性心律失常发生的预测指标,最佳临界值为125.26ms,ROC曲线下面积为0.9218,具有较高的诊断价值;以QTc作为预测指标,最佳临界值为433.32ms,ROC曲线下面积为0.8231,诊断价值中等;以Tp-Te/QT比值作为预测指标,最佳临界值为0.29,ROC曲线下面积为0.9608,诊断价值最高。结论:Tp-Tec,QTc,Tp-Te/QT与AMI患者急性期室性心律失常的发生存在明显正相关,对于室性心律失常的发生均具有预测价值,同时Tp-Tec,QTc及Tp-Te/QT有助于评价AMI患者的预后。
    • 王丹; 薛小临; 杨琳; 李佳娜; 严干新; 王阿利
    • 摘要: 目的 观察辛伐他汀在正常及晚钠电流(INa-L)增大的情况下对离体兔左室心电活动的影响.方法 建立经冠状动脉灌注兔左室楔形组织块标本.实验分为两部分:正常情况组:以自身空白作对照,依次给予10、30、100nmol/L浓度的辛伐他汀;INa-L增大组:使用海葵毒素(ATX-Ⅱ)建立Ia-L增大模型后,依次给予10、30、100 nmol/L浓度的辛伐他汀.记录各组跨壁心电图及动作电位,观察QRS波宽度、QT间期、T波峰值至终点的时程(Tp-e)、Tp-e/QT及动作电位复极90%时程(APD90)在上述分组中的变化,以及是否引发早期后除极(EAD)和尖端扭转型室性心动过速(TdP).结果 ①在正常情况下,辛伐他汀在10、30、100 nmol/L浓度下对QRS波宽度、QT间期、Tp-e间期、Tp-e/QT、APD90均无明显影响(P>0.05).②INa-L增大后,10 nmol/L辛伐他汀对上述电生理指标无明显影响(P>0.05),30 nmol/L及100 nmol/L辛伐他汀则显著延长QT间期和APD90(P<0.01),同时减小Tp-e/QT(P<0.05).且未见EAD及TdP发生.结论 在正常情况下,辛伐他汀对兔离体左室除极及复极活动无明显影响;INa-L增大后,高于治疗浓度的辛伐他汀可延长复极时程,同时显著减小跨壁复极离散度,从而降低致心律失常风险.%Objective Observe the effect of simvastatin on electrical activity of rabbit heart in absence and presence of ATX-Ⅱ,an enhancer of Late INa.Methods Established the arterially perfusing rabbit left ventricular wedge preparations and divided into two parts.In the normal group,we observed QRS duration,QT interval,Tp-e interval,APD90 and Tp-e/QT ratio in the absence and presence of treatment with simvastatin,and in the Late INa Augmenting group,we used ATX-Ⅱ to establish model hearts with Late INa augmenting and then measured those electrophysiological indicators in the absence and presence of treatment with simvastatin.Results In normal hearts,simvastatin at concentrations of 10,30,100 nmol/L had no significant effect on QRS complex,QT interval,Tp-e interval,APD90 and Tp-e/QT ratio (n=6,P>0.05).In the presence of 3 nmol/L ATX-Ⅱ,simvastatin (10 nmol/L) had no significant effect on those electrophysiological indicators,but significantly prolonged QT interval and APD90 and decreased Tp-e/QT ratio at concentrations of 30 nmol/L and 100 nmol/L (n=7,P<0.01).No EADs and TdP occured.Conclusions Simvastatin has no significant effect on depolarization and repolarization activities in rabbit left ventricular wedge preparations.In hearts with INa-L augmenting,simvastatin at higher than therapeutic concentrations could prolong repolarizationduration and increase left ventricular electrical stability,and thus reduces arrhythmogenic risks.
    • 仇军; 张勇
    • 摘要: 目的 探讨麻黄附子细辛汤与二仙生脉汤联合随证加减治疗对慢性心律失常患者跨壁复极离散度的影响.方法 选择北京中医医院顺义医院2012年1月~2016年1月收治的慢性心律失常患者100例作为研究对象,随机分为对照组和观察组,每组50例,对照组采用改善冠状动脉供血、控制血压、调理血脂、抗血小板、纠正心衰等常规治疗,观察组加麻黄附子细辛汤合二仙生脉汤治疗,每天1剂,治疗时间2周.观察两组治疗前、治疗28天后临床症状恢复情况,并对两组治疗前、治疗14天后、治疗28天后的TpTe、TpTe/QT等指标进行比较,观察两组心律表现恢复正常时间、心脏疾病药物治疗总时间及临床疗效,并进行统计学分析.结果 两组患者治疗前眩晕多梦、乏力、胸闷胸痛、心悸气短等临床症状比较差异无统计学意义(P>0.05);观察组患者治疗后眩晕多梦、乏力、胸闷胸痛、心悸气短等临床症状明显低于对照组,且比较差异有统计学意义(P0.05);观察组患者治疗14天、治疗28天TpTe、TpTe/QT均明显低于对照组,且比较差异有统计学意义(P<0.05);对照组患者治疗总有效率为70.0%,观察组治疗总有效率为92.0%.观察组总有效率明显高于对照组,比较差异显著(P<0.05).结论 应用麻黄附子细辛汤与二仙生脉汤联合随证加减治疗能够缩短慢性心律失常患者TpTe间期,可改善心室肌跨壁复极离散度,降低室性心律失常的发生,治疗效果非常明显.
    • 张易民; 张广平
    • 摘要: Objective:To study the correlation of electrophysiological characteristics Tp-ec and Tp-e/QT with myocardi-al injury and oxygen free radical generation in patients with acute myocardial infarction .Methods:Patients who were diagnosed with acute myocardial infarction in our hospital between March 2014 and March 2017 were selected as the AMI group ,and healthy subjects who received physical examination were selected as the control group ,electrocardiography was done to deter-mine Tp-ec and Tp-e/QT ,serum was collected to determine the levels of myocardial injury markers ,oxygen free radical gener-ation indexes and apoptosis indexes ,and peripheral blood was collected to determine the expression of oxygen free radical gen-eration indexes .Results:Tp-ec and Tp-e/QT of AMI group were significantly higher than those of control group ,and serum CK-MB ,cTnI ,H-FABP ,MDA ,sTWEAK ,sFas and sTRAIL contents as well as peripheral blood Nrf-2 ,NRE and HO-1 mRNA expression were significantly higher than those of control group and positively correlated with Tp-ec and Tp-e/QT . Conclusion:Electrophysiological characteristics Tp-ec and Tp-e/QT increase ,and the transseptal dispersion of repolarization increases in patients with acute myocardial infarction ,and they are closely related to myocardial injury and oxygen free radical generation .%目的:研究急性心肌梗死患者电生理特征Tp-ec及Tp-e/QT与心肌损伤、氧自由基生成的相关性.方法:选择在我院诊断为急性心肌梗死的患者作为AMI组、健康体检者作为对照组,进行心电图检查并测定Tp-ec及Tp-e/QT,采集血清并测定心肌损伤标志物、氧自由基生成指标及细胞凋亡指标的含量,采集外周血并测定氧自由基生成指标的表达量.结果:AMI组患者的Tp-ec及Tp-e/QT均显著高于对照组,血清中CK-MB、cTnI、H-FABP、MDA、sTWEAK、sFas、sTRAIL的含量及外周血中Nrf-2、NRE、HO-1的mRNA表达量均显著高于对照组且与Tp-ec及Tp-e/QT的水平呈正相关.结论:急性心肌梗死患者电生理特征Tp-ec及Tp-e/QT升高、跨壁复极离散度增加且与心肌损伤、氧自由基生成密切相关.
    • 薛聪; 华伟; 蔡迟; 丁立刚; 牛红霞; 王靖; 刘志敏; 樊晓寒; 张澍
    • 摘要: 目的 观察心脏再同步治疗除颤器(CRT-D)植入术后T波峰末间期(TpTe)和室性心动过速/心室颤动(VT/VF)事件随时间的变化,探讨心脏再同步治疗(CRT)在不同时期对复极离散度和室性心律失常事件的影响.方法 入选2007年1月至2014年12月在阜外医院初次植入CRT-D的患者62例,根据术后6个月左心室舒张末期内径(LVEDd)绝对值是否较基线水平减小≥10%,分为左心室逆重构组和无逆重构组.分析比较患者术前、术后即刻(≤24 h),1、3、6、12个月的TpTe间期变化及VT/VF事件发生情况.结果 所有患者TpTe在CRT-D植入术后即刻轻度延长,随后呈逐渐缩短趋势;与术前相比,术后6个月[(101.06±10.61) ms对(105.32±11.32) ms,P<0.05]和12个月[(99.5±11.44)ms对(105.32±11.32) ms,P<0.05]明显缩短.逆重构组TpTe在术后6个月[(94.03±11.20) ms对(104.57±12.30) ms,P<0.05]和12个月[(92.24±11.04) ms对(104.57±12.30) ms,P<0.05]也较术前显著缩短;无逆重构组TpTe在术后6、12个月较术前均无改变.经Kaplan-Meier生存分析发现,逆重构组VT/VF事件发生率小于无逆重构组(log-rank test,x3=4.287,P=0.038).结论 CRT-D植入术后TpTe逐渐缩短,需抗心动过速起搏或电除颤治疗的VT/VF事件逐渐减少.左心室逆重构患者的复极离散度和室性心律失常事件发生率改善显著.%Objective To determine the time-dependent effect of cardiac resynchronization therapy(CRT)on dispersion of repolarization and ventricular arrhythmia in heart failure patients.Methods A total of 62 consecutive patents who underwent their first cardiac resynchronization therapy defibrillator(CRT-D) implantation at arrhythmia center of Fuwai Hospital from January 2007 to December 2014 were studied.The electrocardiograms were collected at pre-operation,immediate post operation,1,3,6,and 12 months after device implantation respectively and were analyzed for T-peak to T-end(TpTe).Ventricular tachycardia(VT)/ventricular fibrillation(VF) episodes were obtained through the pacemaker records.Left ventricular(LV) reverse remodeling was defined as the left ventricular end-diastolic dimension(LVEDD) decreased by at least 10%.Changes of TpTe at different periods and VT/VF episodes were compared between LV reverse remodeling and non-reverse remodeling groups.Results TpTe decreased significantly at 6 and 12 months after CRT-D implantation [(105.32±11.32) ms at baseline vs.(101.06±10.61) ms at 6 months(P<0.05)vs.(99.5±11.44) ms at 12 months(P<0.05)].LV reverse remodeling group demonstrated a great reduction of TpTe at 6 and 12 months after CRT-D implantation and had a lower rate of VT/VF episodes (compared with non-reverse remodeling group,log-rank test,x2 =4.287,P =0.038).Conclusion After CRT-D implantation,TpTe and the number of VT/VF episodes decreased over time.The patients with LV reverse remodeling had a grearter reduction of transmural dispersion of repolarization and a lower rate of VT/VF episodes.
    • 薛聪; 华伟; 蔡迟; 丁立刚; 牛红霞; 王靖; 张澍
    • 摘要: 目的:探讨心脏再同步治疗(CRT)对复极离散度和室性心律失常的影响。  方法:入选86例CRT植入患者,根据术后6个月左心室射血分数(LVEF)绝对值是否较基线水平提高≥10%,分为反应组(n=43)和无反应组(n=43)。比较两组患者CRT植入后不同时期QRS间期、校正的QT间期(QTc间期)、T波峰末间期(TpTe间期)等复极离散度指标变化及室性心律失常事件情况。  结果:反应组患者术后1年QRS间期和TpTe间期较术前和术后0.05)。在术后1年中,反应组室性早搏(PVCs)和室性早搏连发(PVC runs)的发生次数,明显少于无反应组[ lgPVCs:(1.78±0.77)vs(2.73±0.61);lgPVC runs:(0.64±0.48)vs(1.98±0.72), P0.05.②During 1 year after CRT implantation, the incidences of PVCs and PVC runs in Response group were much less than those in Non-response group, for lgPVCs: (1.78 ± 0.77) vs (2.73 ± 0.61), for lgPVC runs: (0.64 ± 0.48) vs (1.98 ± 0.72),P<0.05.③Multi liner regression analysis demonstrated that TpTe interval within 24h after CRT implantation was an independent predictor for both lgPVCs: (B=0.143, OR=1.154,P=0.001) and lgPVC runs: (B=0.122, OR=1.047,P=0.001). Conclusion: CRT ventricular reverse remodeling may reduce dispersion of re-polarization and the risk of ventricular arrhythmia, therefore improve the prognosis in relevant patients; TpTe interval within 24h after CRT had the predictive value for ventricular arrhythmia.
    • 蒋芬芬; 张玲玮; 江力勤; 张建勤; 张冉; 赵圣刚; 邓浪; 张祥宇
    • 摘要: 目的:探讨索他洛尔口服后对兔左心室心肌细胞电生理的影响及其发生机制。方法建立冠状动脉灌注的兔左心室楔形心肌模型,应用心电图同步记录技术和浮置玻璃微电极技术,观察索他洛尔口服后兔内外两层心肌动作电位时程(action potential duration ,APD)、Q_T间期及跨壁复极离散度(transmural dispersion of repolarization ,TDR)的变化以及心律失常的发生。结果索他洛尔组兔内、外膜心肌细胞的APD、Q_T间期及TDR在不同刺激周长下均较对照组延长,且以内膜延长为主(均 P<0.05)。索他洛尔组兔心律失常发生率较对照组升高( P<0.05)。结论索他洛尔可明显延长兔内、外膜心肌细胞的APD、Q_T间期,并可增大兔心肌细胞的TDR ,在兔子模型中,应用索他洛尔容易导致心律失常发生。%Objective To explore the effects and mechanism of Sotalol on electrophysiological changes of the left ventricular myocardial cells in New zealand rabbits.Methods The coronary artery perfused wedge myocardial tissue block model of the rabbit left ventricular was established first.And then we observed the changes of action potential duration (APD) of epi_and endomyocardial cells ,on Q_T in-terval and on transmural dispersion of repolarization(TDR) and arrhythmia after Sotalol being taken orally ,using recording electrocardio-gram and floating glass microelectrode.Results APD and TDR of epi_and endomyocardial cells in rabbits of Sotalol group were prolonged compared with the control group ,and there was a preferentially prolonged action potential in the endocardial cells ( P<0.05 ).Inci-dence of arrhythmia was also statistically significant higher than the control group ( P<0.05).Conclusions Sotalol can obviously pro-long the APD and the Q_T interval and also increase the TDR of the rabbits.Using Sotalol in rabbits model may lead to arrhythmia.
    • 马少卫; 于波; 马淑梅
    • 摘要: 目的 探讨心脏再同步化治疗(cardiac resynchronization therapy,CRT)不同起搏模式对终末期心力衰竭患者心室复极的影响.方法 回顾分析51例接受CRT的终末期心力衰竭患者的心电图资料.记录患者自主心律、右室心内膜起搏(RV-endo-P)、左室心外膜起搏(LV-epi-P)及优化后双室起搏(BiV-P)心电图.测量QRS波时限,QT间期、Tp-e(T波顶点到T波结束)间期,并计算QTc间期(校正后QT间期)、QT离散度(QT-d)及Tp-e离散度.并将各起搏模式心电图数据与患者自主心律进行比较.结果 相对患者自主心律,LV-epi-P可显著延长患者QRS波时限、QTc间期及Tp-e间期,并增加QT-d及Tp-e离散度.QRS波时限平均延长23.31 ms(95% CI:16.64~29.98 ms,P<0.01);QTc间期平均延长32.35 ms(95% CI:18.49~46.22 ms,P<0.01);Tp-e间期平均延长21.98 ms(95% CI:13.09~ 30.87 ms,P<0.01);QT-d平均增加27.96 ms(95% CI:19.14~36.78 ms,P<0.01);Tp-e离散度平均增加26.06 ms(95% CI:18.35~33.77 ms,P<0.01).BiV-P可明显缩短QRS波时限,RV-endo-P可显著延长QRS波时限,差异均有统计学意义(P<0.01);BiV-P及RV-endo-P虽有延长QTc间期及减小QT-d、Tp-e间期、Tp-e离散度的趋势,但差异均无统计学意义(P>0.05).结论 LV-epi-P可使终末期心力衰竭患者心室跨壁复极离散度增大,具有潜在的心律失常事件发生风险.建议植入心脏再同步心脏复律除颤器预防恶性室性心律失常致心源性猝死的发生.
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