Methods for Predicting Survival Outcomes in Subjects with Hepatocellular Carcinoma (HCC) or Cholangiocarcinoma (CCA)

摘要

The present disclosure provides a method for generating a predicted survival outcome for subjects with liver cancer. The method preferably comprises the step of preparing a tissue sample of one of the hepatocellular carcinoma or bile duct cancer collected from the subject and the polo-like kinase 1 (PLK1) and epithelial cell traits in the prepared sample. A step of performing an assay based on at least one kinase and / or an assay based on proteomics to quantify transcriptome expression and / or protein expression of conversion 2 (ECT2) and a specific region on the prepared sample. In the step of deriving the ratio of the expression of PLK1 to the expression of ECT2 and the step of generating the predicted survival outcome of the subject based on the derived ratio, the derived ratio is less than a predetermined value. If, the predicted survival outcome of the subject is defined as the first predicted survival outcome, and if the derived ratio is greater than or equal to the predetermined value, the predicted survival outcome of the subject is defined as the second predicted survival outcome. Including the process of The first predicted survival outcome corresponds to an overall survival rate of greater than 40% to 60% in the predetermined period of survival analysis, and the second predicted survival outcome corresponds to the predetermined period of survival analysis. Corresponds to an overall survival rate of 40% to 60% or less.