METHOD OF OBTAINING IMMUNOGENIC NON-HEMOLYTHIC BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, VACCINE AGAINST PIG PLEUROPNEUMONIA (VERSIONS), IMMUNOGENIC AND NON-HAEMOLYTIC STRAIN OF Actinobacillus pleuropneumoniae (VERSIONS)

摘要

FIELD: biotechnologies.;SUBSTANCE: invention relates to field of biotechnology, namely to obtaining vaccine strains, and can be used in veterinary. Bacterium Actinobacillus pleuropneumoniae is modified by introducing deletion, of at least one segment of gene apxIA and, optionally, segment of gene apxIIA, which code transmembrane domain of haemolytic and cytolytic exotoxins Apx. Obtained bacterium is used for production of vaccine against pig pleuropneumonia.;EFFECT: invention allows obtaining attenuated live vaccine against pig pleuropneumonia based on immunogenic non-haemolytic strain of bacterium Actinobacillus pleuropneumoniae.;11 cl, 6 dwg, 3 tbl, 1 ex