METHODS OF TREATMENT OF AUTOSOME-DOMINANT HYPERSHOLESTERYNEMIA ASSOCIATED WITH THE MUTATION OF ACQUISITION OF PCSK9 GENE

摘要

The present invention provides methods for treating autosomal dominant hypercholesterolemia (ADH). According to some embodiments of the present invention, ADH is caused or associated with a function acquisition mutation (MTF) of the gene encoding the PCSK9 enzyme. Thus, the present invention includes methods that involve the selection of a patient with MTF in one or both alleles of the PCSK9 gene and the administration to the patient of a pharmaceutical composition containing the inhibitor PCSK9 enzyme. According to some embodiments of the present invention, the PCSK9 enzyme inhibitor is an anti-PCSK9 antibody, an example of which in this document is mAb316P.