Androgen and Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk.

摘要

This project assessed the association between breast cancer risk and polymorphisms of the androgen receptor (AR) and vitamin D receptor (VDR) genes among subjects in a population-based case-control study in Sweden. From this study population, breast cancer cases and control women have been randomly selected for genomic DNA analysis. The collection of blood or tissue specimens has been funded from other sources; this award was for the measurement of the AR and VDR polymorphisms on 300 cases and 300 controls who never used HRT, and a similar number of cases and controls who used HRT for 4 years of more. We obtained blood or tissue samples from 1569 breast cancer cases, and obtained blood samples from 1524 controls. Genotyping was successful for well over 95% of these. Statistical analyses are complete, and a draft manuscript has been prepared. We found no association between breast cancer risk and the polymorphisms investigated.