维生素D受体基因FokⅠ位点多态性与乳腺癌易感性关系的Meta分析

摘要

Objective:To evaluate polymorphism of VDR Fok Ⅰ and breast cancer by using Meta analysis.Methods:Weipu,Wanfang,CNKI,CBM,PubMed,EMBASE,Ovid,and Cochrane Library databases were employed to search for citations using the MeSH terms as "VDR"," breast cancer"," Fok Ⅰ" and "genetic polymorphism" both in Chinese and English.Meta analysis was conducted by RevMan 5.0 software.Results:The study included 12 studies with a total sample of 20833 cases,of which 8991 cases in case group and 11842 cases in control group.The results showed Fok Ⅰ genotype FF [OR =1.07,95％CI (0.93,1.22),P=0.36] and Ff/FF [OR =1.07,95％CI (0.94,1.21),P =0.30] couldn't decrease the risk of breast cancer.Conclusion:Polymorphism of VDR Fok Ⅰ was not associated with breast cancer.Genotype FF and Ff/FF were not protective factors of breast cancer.%目的:运用Meta分析的方法综合评价维生素D受体基因(VDR) Fok Ⅰ位点多态性与乳腺癌的相关性.方法:以“维生素D受体”、“乳腺癌”、“Fok Ⅰ位点”和“基因多态性”为主题词,检索维普、万方、中国知网全文(CNKI)、中国生物医学文献光盘(CBM)、PubMed、EMBASE、Ovid、Cochrane Library等数据库收集已发表的有关VDR Fok Ⅰ位点多态性与乳腺癌关系的随机对照文献.使用Cochrane系统评价软件RevMan 5.0完成Meta分析.结果:共有12篇病例对照研究纳入本研究,累计样本量为20833例,其中病例组8991例,对照组11842例.Meta分析结果显示,VDR Fok Ⅰ位点基因型FF[OR=1.07,95％ CI(0.93,1.22),P=0.36]和基因型Ff/FF[OR=1.07,95％ CI(0.94,1.21),P=0.30]不能降低乳腺癌的发病率.结论:维生素D受体基因FokⅠ位点多态性与乳腺癌易感性无关,基因型FF和基因型Ff/FF对其没有保护作用.