Chemical Synthesis of a Skeleton Structure of Sperm CD52-A GPI-Anchored Glycopeptide

摘要

Glycosylphosphatidylinositol (GPI)-anchored glycopeptides or glycoproteins are ubiquitously present on eukaryotic cells. For example, CD52 antigen, which is expressed by virtually all human lymphocytes and sperms is a simple GPI-anchored glycopeptide, but it plays a critical role in the human immune and reproduction systems. Sperm CD52 is involved in the human sperm-egg recognition and binding, while antibodies against lymphocyte CD52 have been used to treat several immune system-related diseases.