Regioselective Synthesis of γ-Amino Esters, Nitriles, Sulfones, and Pyrrolidinones by Nickel-Catalyzed Reductive Coupling of Aldimines and Activated Alkenes

摘要

The transition-metal-catalyzed regioselective coupling of two organic π components via a five-membered metallacycle intermediate is one method for the construction of C—C bonds and the synthesis of molecules with multiple functional groups. Among these reactions, the reductive coupling of alkyne/alkyne alkene/alkyne, and alkene/alkene couples has been widely explored by us and others. Similarly, the coupling of alkene/carbonyl and alkyne/carbonyl couples catalyzed by metal complexes has more recently also attracted attention.