Collagen-Targeted MRI Contrast Agent for Molecular Imaging of Fibrosis

摘要

Fibrosis is the formation or development of excess fibrous connective tissue(largely type I collagen)in a tissue as a result of a reparative or reactive process.Fibrosis,or scarring,is a common outcome in many chronic diseases of the heart,kidney,liver,lungs,or vasculature.Hepatic fibrosis is a result of chronic injury in response to insults such as viral hepatitis,alcohol or drug abuse,and increasingly from non-alcoholic steato hepatitis(NASH).Fibrosis is a hallmark of end-stage renal disease.Pulmonary fibrosis occurs in conditions such as chronic obstructive pulmonary disease.