Notoamides A-D: Prenylated Indole Alkaloids Isolated from a Marine-Derived Fungus, Aspergillus sp.

摘要

Marine-derived fungi have proven to be rich sources of structurally novel and biologically active secondary metabolites, which are emerging as a significant resource for new chemicals in drug discovery. During a search for natural products that exhibit pharmacologically interesting activities, we screened extracts derived from marine organisms for cytotoxic activity. Herein we report the isolation, structure elucidation with the absolute stereochemistry, and biological activities of four new doubly prenylated indole alkaloids, the notoamides A-D (1-4).