Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?

摘要

General research into cytochrome P450 (P450) mediated oxidation has led to a consensus view that the highly active, electrophilic Cpd I is responsible for the vast majority of such oxidations (Scheme 1).[1] The much less reactive Cpd 0 has also been proposed as an oxidant in many P450-catalyzed transformations, including C-H hydroxylation, epoxidation, and sulfoxidation (Scheme 1).