Asymmetric Synthesis of Natural Product Inspired Tricyclic Benzopyrones by an Organocatalyzed Annulation Reaction

摘要

The structural frameworks of natural product classes provide evolutionary-selected and biologically prevalidated starting points in vast chemical structure space for compound development in chemical biology and medicinal chemistry research.The synthetic challenges often posed by natural products and analogues thereof call for the development of new enantioselective synthesis methods amenable to the synthesis of compound collections.Recently,a group of natural products with a tricyclic benzopyrone core structure was reported as a new class of inhibitors for bacterial metallo-beta-lactamases.This promising class of inhibitors was proposed for a potential combination treatment of clinically relevant pathogens,in particular against multidrug-resistant strains.