A Solid-Phase Route to ~(18)F-Labeled Tracers,Exemplified by the Synthesis of [~(18)F]2-Fluoro-2-deoxy-D-glucose

Lynda J.Brown; Denis R.Bouvet; Sue Champion

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A Solid-Phase Route to ~(18)F-Labeled Tracers,Exemplified by the Synthesis of [~(18)F]2-Fluoro-2-deoxy-D-glucose

机译：固相合成〜（18）F示踪剂的路线，以[〜（18）F] 2-氟-2-脱氧-D-葡萄糖的合成为例

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Positron emission tomography (PET) is an important diag nostic tool in modern medicine,where it is routinely used to locate and assess abnormalities in oncology,neurology.and cardiology.In addition,PET and microPET are also finding increased applications in the areas of drug discovery and development.

机译：正电子发射断层扫描（PET）是现代医学中重要的诊断工具，通常用于定位和评估肿瘤学，神经病学和心脏病学方面的异常情况。此外，PET和microPET在医学领域也得到了越来越多的应用。发现和发展。

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《Angewandte Chemie》 |2007年第6期|共4页
作者
Lynda J.Brown; Denis R.Bouvet; Sue Champion;
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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
fluorine; positron emission tomography; radiopharmaceuticals; solid-phase synthesis; synthetic methods;

机译：氟;正电子发射断层显像;放射性药物;固相合成;合成方法;

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专利

1. A Solid-Phase Route to ~(18)F-Labeled Tracers,Exemplified by the Synthesis of [~(18)F]2-Fluoro-2-deoxy-D-glucose [J] . Lynda J.Brown, Denis R.Bouvet, Sue Champion Angewandte Chemie . 2007,第6期

机译：固相合成〜（18）F示踪剂的路线，以[〜（18）F] 2-氟-2-脱氧-D-葡萄糖的合成为例
2. ~(18)F-FESB: synthesis and automated radiofluorination of a novel ~(18)F-labeled pet tracer for beta-amyloid plaques [J] . Piyush Kumar, Weizhong Zheng, Stephen A. McQuarrie, Journal of Labelled Compounds and Radiopharmaceuticals . 2005,第13期

机译：〜（18）F-FESB：新型〜（18）F标记的宠物示踪剂的合成和自动放射性氟化，用于β-淀粉样蛋白斑块
3. ~(18)F-Labeled Aryl-Tracers through Direct Introduction of [~(18)F]fluoride into Electron-Rich Arenes [J] . Mitja Kova?, Sylvie Mavela, Marko Anderluhb Current organic chemistry . 2013,第23期

机译：通过将[〜（18）F]氟化物直接引入到富含电子的芳烃中，〜（18）F标记的芳烃追踪剂
4. Synthesis of ¹⁸F-labeled probes on EWOD platform for Positron Emission Tomography (PET) preclinical imaging [C] . Chen S., Keng P.Y., van Dam R.M., 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems . 2011

机译：在EWOD平台上合成^{18 F标记的探针，用于正电子发射断层扫描（PET）临床前成像}
5. Design and synthesis of P-selectin inhibitors targeting cancer growth and metastasis and Microwave assisted radio-fluorodenitration and pharmacological studies of (4-[fluorine-18]-fluorophenyl)-triphenylphosphonium nitrate (fluorine-18-PTPP) as a cardiac positron emission tomography tracer . [D] . Afroze, Roushan. 2012

机译：靶向癌症生长和转移的P-选择素抑制剂的设计与合成以及（4- [氟18]-氟苯基）-硝酸三苯phosph（氟18-PTPP）作为心脏正电子发射断层扫描的微波辅助放射性氟滴定和药理研究示踪剂。
6. Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety 18FFMISO and 18FPM-PBB3 via 18Fepifluorohydrin [O] . Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, 2021

机译：含有3-氟-2-羟丙基部分18F FMISO和18F PM-PBB3通过18F ePiforoHyrin的自动覆盖合成器的两种18F标记的示踪剂。
7. Reusable electrochemical cell for rapid separation of 18Ffluoride from 18Owater for flow-through synthesis of 18F-labeled tracers [O] . Saman Sadeghi, Vincent Liang, Shilin Cheung, 2013

机译：可重复使用的电化学电池，用于从18O水中的18F氟化物的快速分离，通过合成18F标记的示踪剂

A Solid-Phase Route to ~(18)F-Labeled Tracers,Exemplified by the Synthesis of [~(18)F]2-Fluoro-2-deoxy-D-glucose

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