Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV-Induced Lesion

摘要

The investigation of long-distance charge transport through DNA is complicated because experimental results depend upon the charge injection and charge detection systems used. The rate of charge injection into a DNA base depends on the redox potential of the injection system and also on the structure of the DNA base since distortions of the base may change its orbital overlap pattern and solvation energy. The nature of the charge detection system used to analyze the arriving charge after its multistep transport through DNA is also of crucial importance in studies on long-distance charge transport. compared to those of dialkyl ketones.[8] Thus, a ketyl radicalanion should reduce an adjacent thymine base. We therefore synthesized the thymidine derivative 3 by attaching the ketyl radical precursor 2 to a thymine base (Scheme 1).