Criteria for Efficient Transport of Excess Electrons in DNA

摘要

Extensive studies on charge transfer in DNA have provided significant insight into the molecular mechanisms of DNA damage induced by high- and low-energy radiation and by chemical oxidants.[8] Appreciation of the conducting properties of DNA has also inspired the development of new nanoscale intelligent materials and chemical sensors. Results from both theoretical and experimental approaches nowseem to suggest that electron-deficient intermediates generated from one-electron oxidation of DNA can undergo hole transfer (HT) between guanine (G) residues by singlestep tunneling (G hopping), by multistep tunneling through intervening adenine (A) residues (A hopping), and by polaron-like hopping of delocalized radical cations.