Action of atrop-Abyssomicin C as an Inhibitor of 4-Amino-4-deoxychorismate Synthase PabB

摘要

Among biosynthetic pathways,chorismate is an important and central biosynthetic metabolite that branches off to the biosynthesis of aromatic amino acids Trp,Tyr,and Phe,but also to p-aminobenzoic acid(pABA).p-Aminobenzoic acid is a component of the biosynthesis of tetrahydrofolate.Corresponding biosynthesis enzymes of pABA and tetrahydrofolate occur in many microorganisms and parasites,but not in humans,which makes pABA biosynthesis an interesting target for anti-infective agents.