Phototoxicity of Peptidoconjugates Modulated by a Single Amino Acid

摘要

OxidatIVe stress resulting from the intracellular release of chemical oxidants or free radicals is known to exert deleterious effects on biological function.In cells,exposure to light or sensitizers can produce singlet oxygen(~1O_2),a highly reactIVe,mutagenic,and genotoxic species that induces oxidatIVe stress.These properties have been harnessed in photodynamic chemotherapy,an anticancer treatment that involves the photosensitization of ~1O_2 to promote cell death within solid tumors.