Fluoromorphic Substrates for Fatty Acid Metabolism: Highly Sensitive Probes for Mammalian Medium-Chain Acyl-CoA Dehydrogenase

摘要

In contrast to the accepted view in biological sciences that enzymes are highly selective for their physiological substrates, substrate promiscuity is a widespread phenomenon.[1] Such functional flexibility may often be observed with enzymes involved in the metabolism of an array of substrates, and examples extend beyond the well-known xenobiotic metabolism.