Immortalizing a Transient Electrophile for DNA Cross-Linking

摘要

Quinone methide intermediates (QMs) are integral to the activity of numerous natural products and synthetic compounds that,for example,may function as anticancer drugs,mechanism-based inactivators,or self-immolative dendrim-ers.The potential for these intermediates to act reversibly has a significant influence on their effective longevity,the resulting product distribution,and their general utility.