Biopolymer Skeleton Produced by Rhizobium radiobacter: Stoichiometric Alternation of Glycosidic and Amidic Bonds in the Lipopolysaccharide O‐Antigen

Speciale Immacolata; Di Lorenzo Flaviana; Gargiulo Valentina; Erbs Gitte; Newman Mari‐Anne; Molinaro Antonio; De Castro Cristina

摘要

Abstract > The lipopolysaccharide (LPS) O‐antigen structure of the plant pathogen Rhizobium radiobacter strain TT9 and its possible role in a plant‐microbe interaction was investigated. The analyses disclosed the presence of two O‐antigens, named Poly1 and Poly2. The repetitive unit of Poly2 constitutes a 4‐α‐ <sc>l</sc> ‐rhamnose linked to a 3‐α‐ <sc>d</sc> ‐fucose residue. Surprisingly, Poly1 turned out to be a novel type of biopolymer in which the repeating unit is formed by a monosaccharide and an amino‐acid derivative, so that the polymer has alternating glycosidic and amidic bonds joining the two units: 4‐amino‐4‐deoxy‐3‐O‐methyl‐ <sc>d</sc> ‐fucose and (2′R,3′R,4′S)‐ N ‐methyl‐3′,4′‐dihydroxy‐3′‐methyl‐5′‐oxoproline). Differently from the O‐antigens of LPSs from other pathogenic Gram‐negative bacteria, these two O‐antigens do not activate the oxidative burst, an early innate immune response in the model plant Arabidopsis thaliana, explaining at least in part the ability of this R. radiobacter strain to avoid host defenses during a plant infection process. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 研究了植物病原体辐射杆菌菌株TT9的脂多糖（LPS）O-抗原结构及其在植物微生物相互作用中的可能作用。分析公开了存在两种O-抗原，命名为Poly1和Poly2。 Poly2的重复单元构成4-α- <sc> l </ sc> -rhamnose与3-α-相关联 <sc> d </ sc> - 余残留物。令人惊讶的是，Poly1原来是一种新型的生物聚合物，其中重复单元由单糖和氨基酸衍生物形成，使得聚合物具有交替的糖苷和酰胺键连接两个单元：4-氨基-4-脱氧-3-O-甲基 - <sc> d </ sc> - 豆荚和（2'r，3'r，4'） - n </ i> - 甲基-3'，4'-二羟基-3'-甲基-5'-氧化申请）。与其他致病革兰氏阴性细菌的LPS的O-抗原不同，这两个O-抗原不会激活氧化爆发，在模型植物拟南芥中提前先天的免疫反应，至少部分地解释了这个r的能力。辐射杆菌菌株以避免植物感染过程中的宿主防御。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第16期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Speciale Immacolata&option=202" target="_blank" rel="nofollow">Speciale Immacolata;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Di Lorenzo Flaviana&option=202" target="_blank" rel="nofollow">Di Lorenzo Flaviana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gargiulo Valentina&option=202" target="_blank" rel="nofollow">Gargiulo Valentina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Erbs Gitte&option=202" target="_blank" rel="nofollow">Erbs Gitte;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Newman Mari‐Anne&option=202" target="_blank" rel="nofollow">Newman Mari‐Anne;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Molinaro Antonio&option=202" target="_blank" rel="nofollow">Molinaro Antonio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=De Castro Cristina&option=202" target="_blank" rel="nofollow">De Castro Cristina;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Chemical SciencesUniversity of NapoliVia Cintia 4 80126 Napoli Italy;</p> <p>Department of Chemical SciencesUniversity of NapoliVia Cintia 4 80126 Napoli Italy;</p> <p>Department of Chemical SciencesUniversity of NapoliVia Cintia 4 80126 Napoli Italy;</p> <p>Department of Health TechnologyTechnical University of Denmark Kemitorvet2800 Kgs. Lyngby Denmark;</p> <p>Department of Plant and Environmental SciencesUniversity of CopenhagenThorvaldsensvej 40 1871 Frederiksberg Denmark;</p> <p>Department of Chemical SciencesUniversity of NapoliVia Cintia 4 80126 Napoli Italy;</p> <p>Department of Agricultural SciencesUniversity of NapoliVia Università 100 80055 Portici (NA) Italy;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biopolymers&option=203" rel="nofollow">biopolymers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carbohydrates&option=203" rel="nofollow">carbohydrates;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=saccharides&option=203" rel="nofollow">saccharides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=structural biology&option=203" rel="nofollow">structural biology;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=structure elucidation&option=203" rel="nofollow">structure elucidation;</a> </p> <div class="translation"> 机译：生物聚合物;碳水化合物;糖类;结构生物学;结构阐明; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" 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class="tuijian_auth tuijian_authcolor"> . 毕宁宁</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120114005048.html">一种苏黎世克罗诺杆菌5型脂多糖O-抗原寡糖片段及其制备方法与应用</a> <b>[P]</b> . <span> 中国专利： CN114085255A </span> <span> . 2022-02-25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120915034.html">化合物肉桂基-(6＇-O-α-L-吡喃阿拉伯糖)-O-β-D-吡喃葡萄糖苷在制备抗抑郁药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN101455673B </span> <span> . 2012.03.21</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130470152466.html">Procedure of producing the glycosidic Bond related antigens derived from cancer.</a> <b>[P]</b> . <span> 外国专利：  ES8700056A1 </span> <span> . 1987-01-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> 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