Direct Synthesis of a Thiolato-S and Sulfinato-S Co~(III) Complex Related to the Active Site of Nitrile Hydratase:A Pathway to the Post-Translational Oxidation of the Protein

摘要

A group of sulfur-oxidized species found in biological systems includes sulfenic,sulfinic,and sulfonic acids derived from cysteine.Currently "sulfur-oxidized" proteins are known to carry only one type of modification at a time,except for nitrile hydratase (NHase),which is the only system known to contain thiolate,sulfenate,and sulfinate groups in close proximity through coordination to a metal center.