17beta-Estradiol-Associated Stealth-Liposomal Delivery of Anticancer Gene to Breast Cancer Cells

摘要

Estrogen receptor(ER),a member of the nuclear hormone receptor superfamily,is classically known to express as intracellular steroid receptor.It shows up predominantly in estrogen-responsive organs,such as ovary,uterus,and mammary cells.ER possesses mainly genomic properties but nongenomic,steroidal functions are also known.Interestingly,classical ERs are implicated in several cancer pheno-types in the female population and are expressed in 60-80 % of breast cancer samples.These receptors are mostly confined to the primary stage of the tumor,and therefore endocrine-based therapy is generally used in the initial stages of neoplastic transformation.