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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Necessity of adjuvant concurrent chemo-radiotherapy in D2-resected LN-positive gastric cancer
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Necessity of adjuvant concurrent chemo-radiotherapy in D2-resected LN-positive gastric cancer

机译：佐剂同时化疗在D2切除的LN阳性胃癌中的必要性

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摘要

Background and purposeTo investigate the role of adjuvant concurrent chemo-radiotherapy (CCRT) by analyzing the outcomes of adjuvant CCRT versus chemotherapy alone (CA) in patients with D2-resected gastric cancer with lymph node (LN) metastasis. Materials and methodsPatients with gastric cancer from the institutional registry who underwent curative D2 and R0 resection from December 2004 to January 2013 followed by adjuvant CCRT or CA and demonstrated pathologically confirmed LN metastasis without distant metastasis were included in the study. ResultsA total of 1633 patients were included (909 patients in the adjuvant CCRT group and 724 patients in the CA group), and median follow-up was 65.4?months (range, 3.9–141.7?months). There was a significant difference in age (p?
机译：背景和puposeto通过分析D2切除胃癌患者的辅助CCRT与化疗的辅助和化疗，淋巴结（LN）转移来研究佐剂并发化疗（CCRT）的作用。从2004年12月到2013年12月到2013年1月的疗法D2和R0切除的机构登记处具有胃癌的材料和方法分离，其次是佐剂CCRT或CA，并在该研究中纳入了病理证实的LN转移。结果总共包括1633名患者（佐剂CCRT组909名患者，CA组中的724名患者），中位随访时间为65.4？月（范围，3.9-141.7？月份）。年龄差异有显着差异（p？<？0.0001），Lauren的分类（p？= 0.02），Ln转移的数量（p？<β0101）和pn阶段（p？<Δ0101）之间的ccrt和Ca组。在CCRT组中的419例（25.7％）的患者中，在CCRT组中的236（26.0％）中检测到随访，183（25.3％）。在单变量分析中CCRT和Ca组之间的复发存活率（RFS）没有显着差异（P？= 0.92）。调整后，PT / PN阶段和麻纹侵袭在多变量COX回归分析中显示出统计学意义;然而，CCRT组中的RFS显着高（P？= 0.03，危险比0.801,95％置信区间0.658-0.975）。结论CCRT组调整后的RFS比D2切除LN转移性胃癌的CA组显着高。

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  • 作者

    Jeong Il Yu; Do Hoon Lim; Jeeyun Lee; Won Ki Kang; Se Hoon Park; Joon Oh Park; Young Suk Park; Ho Yeong Lim; Seung Tae Kim; Su Jin Lee; Sung Kim; Tae Sung Sohn; Jun Ho Lee; Ji Yeong An; Min Gew Choi; Jae Moon Bae; Hye Seung Kim; Soohyun Ahn;

  • 作者单位

    Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine;

    Statistics and Data Center Samsung Medical Center;

    Department of Mathematics Ajou University;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Gastric cancer; Adjuvant; Concurrent chemo-radiotherapy; Chemotherapy; Recurrence;

    机译：胃癌;佐剂;同时化疗 - 放射疗法;化疗;再次发生;

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