FDG-PET Studies of Semantic Dementia; A Review

摘要

Semantic Dementia (SD) is classified as a type of Frontotemporal Lobar Degeneration (FTLD) characterized by progressive impairment of conceptual knowledge, accounting for approximately 30% of cases of FTLD. Clinical symptoms and brain Magnetic Resonance (MR) imaging are helpful to reach the diagnosis in the advanced stage, but brain positron emission tomography with [~18F] Fluoro-2-Deoxy-D-Glucose (FDG-PET) might be useful to evaluate and distinguish the early stage of SD. This review summarizes 9 studies using FDG-PET with either SPM or three-dimensional stereotactic surface projection statistical software to elucidate the features of SD. The main hypome-tabolic lesions associated with SD were located in the bilateral temporal lobes. The so-called core lesions were predominantly located in the left and anterior and lower parts of the temporal lobe.