Controlled drug release from bifunctionalized mesoporous silica

摘要

Serial of trimethylsilyl-carboxyl bifunctionalized SBA-15 (TMS/COOH/SBA-15) have been studied as carriers for controlled release of drug famotidine (Famo). To load Famo with large capacity, SBA-15 with high content of carboxyl groups was successfully synthesized by one-pot synthesis under the assistance of KCl. The mesostructure of carboxyl functionalized SBA-15 (COOH/SBA-15) could still be kept even though the content of carboxyl groups was up to 57.2%. Increasing carboxyl content Could effectively enhance the loading capacity of Famo. Compared with pure SBA-15, into which Famo could be hardly adsorbed, the largest drug loading capacity of COOH/SBA-15 Could achieve 396 9 mg/g The release of.. Famo from mesoporous Silica Was Studied ill simulated intestine fluid (SIF, pH = 7.4). For COOH/SBA-15, the release rate of Famo decreased with narrowing pore size. After grafting TMS groups Oil the Surface of COOH/SBA-15 with hexamethyldisilazane, the release of Famo was greatly delayed with the increasing content of TMS groups. (C) 2008 Elsevier Inc. All rights reserved.