Product-Derived Bimetallic Palladium Complex Catalyzes Direct Carbonylation of Sulfonylazides

摘要

A novel product-derived bimetallic palladium complex catalyzes a sulfonylazide-transfer reaction with the sigma-donor/pi-acceptor ligand CO, and is advantageous given its broad substrate scope, high efficiency, and mild reaction conditions (atmospheric pressure of CO at room temperature). This methodology provides a new approach to sulfonylureas, which are present in both pharmaceuticals and agrochemicals. The synthesis of Glibenclamide on a gram scale further revealed the practical utility of this procedure. Mechanistically, the generation of a bridged bimetallic palladium species derived from the product sulfonylurea is disclosed as the crucial step for this catalytic cycle.