Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position

摘要

A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The CH bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.