Non-coyalent Single Transcription Factor Encapsulation Inside a DNA Cage

摘要

Regulation of gene expression is fundamental for cell development, maintenance, and growth. Gene regulation occurs mainly at the level of transcription, controlled primarily by DNA-binding proteins known as transcription factors (TFs). For example, the delivery of just four TFs to fully differentiated cells can cause them to revert to a stem-cell-like state, offering promise for regenerative medicine. The ability to influence gene regulation by tuning intracellular TF levels would constitute a powerful method for the study of regulation pathways or the development of therapeutic applications.