Direct Titaniuin-Mediatei Conversion of Ketones into Enamides with Ammonia and Acetic Anhydride

摘要

N-Acyl enamides are useful compounds in organic synthesis. In the realm of catalytic asymmetric hydrogenation, they are among the most exhaustively studied class of substrates, and provide access to valuable chiral amine building blocks. These substrates have also demonstrated broad utility in catalytic asymmetric C-C bond forming processes such as aza-ene, Michael, Friedel-Crafts, cycloaddition, and arylation reactions.