Sequence-Regulated Radical Polymerization with a Metal-Templated Monomer: Repetitive ABA Sequence by Double Cyclopolymerization

摘要

In nature, macromolecules are generated by elaborate mechanisms, often involving a template, in which the sequence of repeating units (i.e., monomers) along a main chain is perfectly programmed or regulated. In peptides, for example, the repeat unit sequence is well-defined, although as many as 20 amino acid comonomers are involved in the polymerization process. Thanks to these well-defined sequences, even a single molecule of a biologically formed polypeptide (protein) forms a specific structure through hydrogen-bond-directed folding to efficiently function as, for example, an enzyme.