Nucleophilic α-Arylation and α-Alkyiation of Ketones by Polarity Inversion of N-AIkoxyenamines: Entry to the Umpolung Reaction at the α-Carbon Position of Carbonyl Compounds

摘要

Umpolung reactions have been developed as unconventional methods for the synthesis of biologically active target molecules. Polarity inversions of the carbonyl group are known in stoichiometric dithiane chemistry and more recently in catalytic NHC chemistry, in which acyl anion equivalents that are generated by the umpolung of reactivity of the carbonyl carbon react with the electrophile.