Pd~(II)-Catalyzed CH Olefmation of N-(2-Pyridyl)sulfonyl Anilines and Arylalkylamines

摘要

The metal-catalyzed direct C—H olefination (Fujiwara-Mor-itani reaction) has emerged as a powerful method for the introduction of functional diversity and structural complexity into arene compounds because of its chemical versatility and its environmental advantages. In spite of the tremendous progress made in this field, some important challenges still remain. Very often the directing groups used for promoting the carbometallation of a proximal C-H bond are difficult to remove, thus compromising the synthetic usefulness of the procedures. In addition, the tether length of the directing group is typically found to be crucial for reactivity. A tether that is one or two atoms longer frequently leads to insufficient or no reactivity.