Palladium(II)-Catalyzed Regioselective Direct C2 Alkenylation of Indoles and Pyrroles Assisted by the N-(2-Pyridyl)sulfonyl Protecting Group

摘要

Driven by its synthetic power and environmental friendliness, C-C bond-forming reactions through catalytic activation of C_(sp)-H bonds constitutes a hot area of research. Since the pioneering work by Murai et al. and Fujiwara and coworkers, remarkable progress has been made in this field, with palladium occupying a prevalent position. Most of these procedures rely on the use of a coordinating functionality that aids in the transition metal mediated functionaliza-tion of a proximal C-H bond.