Differentiation between Structurally Homologous Shiga 1 and Shiga 2 Toxins by Using Synthetic Glycoconjugates

摘要

Shiga toxins 1 and 2 (Stx1 and Stx2) are major virulence factors of Escherichia coli 0157:H7 and have been included on the list of Select Biothreat Agents.Of the estimated 70000 E.coli 0157:H7 cases of disease per year in the United States,10-15% develop hemolytic uremic syndrome (HUS);3-5 % succumb during the acute phase of the disease;and an equivalent number suffer brain damage and renal failure.