Hybrid toxin containing Shiga toxin subunit or Shiga toxin-like toxin subunit fused to Escherichia coli heat labile enterotoxin subunit and vaccine thereof

摘要

The present invention relates to a hybrid bacterial toxin subunit, to a hybrid bipartite bacterial toxin and to nucleic acid molecules comprising a nucleotide sequence encoding such bacterial toxins. Furthermore, the invention relates to vaccines comprising bacterial toxins and to their use in vaccines. Finally, the invention relates to methods for the preparation of such vaccines and to the use of such bacterial toxins for the manufacture of such vaccines.