Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1 - J11

摘要

The anti-bacterial substance, AVS-03d, isolated from the culture of marine Pseudoatteromonas sp. A1-J11 was separated by HPLC with a C_(18) column. The chemical structure of AVS-03d was identified as 2-n-pentyl-4-quinolinol (C_(14)H_(17)NO = 215.13) on the basis of mass spectrometry and NMR spectroscopy. AVS-03d showed strong inhibitory activity against Vibrio harveyi strains as compared with other quinolinol compounds, suggesting that the length of the alkyl side chain of the compound is important for anti-bacterial activity.