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Salicylaldehyde azine cluster formation observed by cold-spray ionization mass spectrometry

机译:冷喷雾电离质谱法观察到水杨醛嗪簇的形成

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We installed a cold-spray ionization (CSI) source on a mass spectrometer to investigate the self-assembly behavior of an aggregation-induced emission enhancement system. Using a CSI source and the three-dimensional platform, a self-assembly system of a salicylaldehyde azine (SAA) was studied in mixture solution. This method permitted the determination of the structural information of the solution state, which cannot be detected by conventional mass spectrometry. In addition to the [M~+H]~+ ion (M is the SAA molecule), many major ion clusters such as [2M~+Na]~+ at m/z 503, [3M~+Na] ~+ at m/z 743, [4M~+Na]~+ at m/z 983 and higher order aggregates were observed in the CSI mass spectra. However, many fragment ions, with the exception of cluster ions, appeared with high abundance when the ESI ion source was used due to the desolvation chamber temperature, suggesting that some aggregation can be detected at low temperatures. To investigate the effect of solvent on the aggregation, the CSI-mass spectrometry (MS) experiments of SAA in absolute ethanol solution and ethanol/water (good/poor solvent) mixture solution were conducted. The most abundant ion peak was protonated SAA (m/z 241) in absolute ethanol, but many cluster ions and some multiple charged ion peaks were observed after adding a small amount of water into the ethanol solution. The results showed good agreement with that inferred by the combinational analysis of scanning electron microscope and fluorescence microscopy, indicating that CSI-MS is capable of providing self-assembly information of labile molecules in the solution state.
机译:我们在质谱仪上安装了冷喷雾电离(CSI)源,以研究聚集诱导的发射增强系统的自组装行为。使用CSI源和三维平台,研究了混合溶液中水杨醛嗪(SAA)的自组装系统。该方法允许确定溶液状态的结构信息,这是常规质谱法无法检测到的。除了[M〜+ H]〜+离子(M是SAA分子)外,许多主要离子簇,例如m / z 503的[2M〜+ Na]〜+,m / z 503的[3M〜+ Na]〜+在CSI质谱图中观察到m / z 743,m / z 983处的[4M〜+ Na]〜+和更高阶的聚集体。但是,由于去溶剂室的温度,当使用ESI离子源时,许多簇离子(簇离子除外)以高丰度出现,这表明在低温下可以检测到一些聚集。为了研究溶剂对聚集的影响,在无水乙醇溶液和乙醇/水(良/劣溶剂)混合物溶液中进行了SAA的CSI质谱分析(MS)实验。在无水乙醇中,最丰富的离子峰是质子化SAA(m / z 241),但是在向乙醇溶液中添加少量水后,观察到许多簇离子和一些带多个电荷的离子峰。结果与扫描电子显微镜和荧光显微镜相结合的分析结果相吻合,表明CSI-MS能够提供溶液状态下不稳定分子的自组装信息。

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