Synthesis and Antimicrobial Activity Evaluation of Novel Oxadiazino/Thiadiazino-Indole and Oxadiazole/Thiadiazole Derivatives of 2-Oxo-2H-benzopyran

摘要

A series of novel oxadiazino/thiadiazino-indole and oxadiazole/thiadiazole derivatives of 2-oxo-2H-benzopyran were synthesized and evaluated for their antimicrobial activities against the bacteria Staphylococcus aureus, Salmonella typhi, and Escherichia coli and two fungal species Candida albicans and Aspergillus niger. The antibacterial activities were expressed as minimum inhibitory concentration (MIC_(50)) in microgram per milliliter. The title compounds 4b and 10b revealed promising antibacterial activity whereas 6d, 7d, 9d, and 10b exhibited significantly impressive antifungal activity.