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Alcohol Biomarkers as Tools to Guide and Support Decisions About Intoxicated Driver Risk

机译:酒精生物标志物作为指导和支持有关醉酒驾驶员风险的决策的工具

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摘要

Objectives: This article describes the results of a pilot study that used alcohol biomarkers to guide decisions about driving under the influence (DUI) driver risk in the United States, replicating a European best practices model. The pilot tested whether biomarkers (1) can help the assessor identify high-risk drivers who continue to drink heavily after their arrest and (2) detect relapses in drivers enrolled in their drivers’ safety plans. Methods: These questions were addressed using two biomarkers, carbohydrate-deficient transferrin (CDT), and the Early Detection of Alcohol Consumption (EDAC) test, to evaluate the drinking behavior in repeat offenders during the assessment interview (baseline) and at 3, 6, 9, and 12 months’'follow-up. The cutoff used to determine heavy drinking at baseline was 2.2 percent CDT and 40 percent P-positive for EDAC. A 30 percentage point increase in biomarker value from an abstinent baseline signaled a relapse and a 30 percentage point decrease in biomarker value from a previous positive measure signaled reduced drinking/abstinence. Results: The results show that the EDAC used alone identified 18 percent of drivers as heavy drinkers at baseline compared to 5 percent for CDT and 8 percent for GGT. The best detection rate was achieved with the EDAC-CDT combination, which captured heavy drinking in 20 percent of the repeat offenders at baseline, most of whom (68%) denied drinking at the assessment interview. During follow-up, 52 percent of drivers abstained/reduced their drinking, almost 20 percent experienced a relapse, and 30 percent remained noncompliant with testing. Drivers who relapsed were less likely to be employed full-time (67 versus 84%) or married (17 versus 30%) compared to those who abstained. Of the drivers who relapsed, 80 percent returned to abstinence or reduced their drinking after biomarker information was used as brief intervention by the counselors. Conclusion: Biomarker testing improved the assessment and monitoring of repeat offenders in this pilot because it provided an objective tool to identify high-risk drivers allowing for better treatment recommendations and helped identified drivers who relapsed during follow-up to facilitate a brief intervention by the counselor that resulted in reduced alcohol consumption. These results contribute to establish evidence based practices in highway safety and are setting up new guidelines in the United States to reduce drunk driving.
机译:目标:本文介绍了一项试点研究的结果,该研究使用酒精生物标志物来指导有关在美国影响驾驶(DUI)驾驶员风险的驾驶决策,并复制了欧洲最佳实践模型。飞行员测试了生物标记物(1)是否可以帮助评估者识别出被捕后仍继续大量饮酒的高风险驾驶员,以及(2)发现参加其驾驶员安全计划的驾驶员是否复发。方法:使用两个生物标记物,即碳水化合物缺乏的转铁蛋白(CDT)和酒精摄入的早期检测(EDAC)测试来解决这些问题,以评估在评估访谈中(基线)以及3、6岁时重复犯案者的饮酒行为,9个月和12个月”。用于确定基线重度饮酒的临界值是EDAC的CDT为2.2%,P阳性为40%。生物标志物值从禁食基线增加30个百分点表示复发,生物标志物值从先前的阳性测量值降低30个百分点表示饮酒/禁欲降低。结果:结果表明,仅使用EDAC就能确定基线时有18%的驾驶员为重度饮酒者,而CDT的驾驶员为5%,GGT的驾驶员为8%。 EDAC-CDT组合的检测率最高,在基线时有20%的屡犯者重度饮酒,其中大多数(68%)在评估访谈中拒绝饮酒。在随访过程中,有52%的驾驶员戒酒/减少饮酒,近20%的人复发,还有30%的人不符合测试要求。与弃权的司机相比,复发的司机不太可能全职工作(67%vs 84%)或已婚(17%vs 30%)。在复发的驾驶员中,有80%的人在将生物标志物信息用作辅导员的简短干预后恢复了节制或减少了酒量。结论:生物标志物测试改进了该试验中重复犯人的评估和监测,因为它提供了客观的工具来识别高危驾驶者,从而提供更好的治疗建议,并帮助识别出在随访期间复发的驾驶者,以利于辅导员的简短干预。从而减少了酒精消耗。这些结果有助于建立基于证据的高速公路安全实践,并正在美国建立新的指南以减少酒后驾车。

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