Skin delivery aspects of benzoyl peroxide-loaded solid lipid nanoparticles for acne treatment

摘要

Background: Benzoyl peroxide (BPO) has been a mainstay of topical acne treatment for years. However, is frequently accompanied by cutaneous irritation and erythema. To reduce these side effects many novel drug delivery systems have been developed in the past, of which solid lipid nanoparticles (SLN) demonstrate clear dominance. Hence, we developed a facile method to prepare stable SLN of BPO and evaluated their anti-bacterial activity. Results: BPO-SLN optimized using 23 full factorial design provided high occlusion factor, low permeation rate, increased drug deposition, reduced skin irritation and strong anti-bacterial activity in contrast with marketed product. Conclusion: Desired goals were achieved by factorial design approach in shortest possible time with minimum number of experiments. The developed BPO-SLN system provided controlled drug release, thereby reducing the well-known side effects.