Redox proteomics studies of in vivo amyloid beta-peptide animal models of Alzheimer's disease: Insight into the role of oxidative stress

摘要

Alzheimer's disease (AD) is an age-related neurodegenerative disease. AD is characterized by the presence of senile plaques, neurofibrillary tangles, and synaptic loss. Amyloid P-peptide (AP), a component of senile plaques, has been proposed to play an important role in oxidative stress in AD brain and could be one of the key factors in the pathogenesis of AD. In the present review, we discuss some of the AD animal models that express AP, and compare the proteomics-identified oxidatively modified proteins between AD brain and those of AP models. Such a comparison would allow better understanding of the role of AP in AD pathogenesis thereby helping in developing potential therapeutics to treat or delay AD.