Metabolic fuel selection: general integration at the whole-body level

摘要

In the present overview I will attempt to address biochemical mechanisms that regulate fuel selection in tissues and their relationship to coordination which is effected through regulation of endocrine and other sensor cells which monitor circulatingconcentrations of fuels and adjust supply and demand. Particular emphasis is placed on longer-term regulation of glucose oxidation, by effects of fatty acids on reversible phosphorylation in the mitochondrial pyruvate dehydrogenase (PDH) complex (EC 1.2.4.1, 2.3.1.12, 1.6.4.3) and its likely further involvement in regulating the secretion of insulin and other hormones. References are limited to reviews and some recent key papers.