SYNTHESIS, PROPERTIES, STRUCTURE AND BIOACTIVITY IN VITRO OF MONONUCLEAR COMPLEXES OF MANGANESE AND NICKEL WITH HYDROXYETHYLTRIBENZIMIDAZOLYLMETHYL ETHYLENE DIAMINE

摘要

Six novel mononuclear complexes, MnCI(2)L . H2O, Mn(SCN)(2)L . 2H(2)O, Mn(ClO2)(2)L . 2H(2)O, NiCl(2)L . 2H(2)O, Ni(SCN)(2)L . H2O, Ni(ClO4)(2)L (L = N-hydroxyethyl-N,N',N'-tribenzimidazolylmethyl ethylene diamine), have been synthesized and characterized. The UV-visible spectra of nickel complexes reveal that L is a weak field ligand. The ESR spectra indicate the asymmetric electronic environment of the manganese ion in its complex. The crystal and molecular structures of Ni(SCN)(2)L . H2O were determined by X-ray diffraction analysis. The nickel ions have distorted octahedral symmetry. The preliminary results of bioassay of the complexes showed that monomanganeses have antitumour activities in vitro. [References: 13]