摘要：＜正＞ Variation of the content of some traceelements in tumor tissues is closely related tothe occurrence and development of the tumor.We observed and measured the Cu2+,Zn2+ and Mg2+ contents and Cu2+/Zn2+ ratioin 16 cases of gliomas.Ten of them weretaken from 10 male,6 from female,and theage of the patients ranged from 7 to 54 yearsold.The tumors used in the present studyare shown in Table 1.All the diagnosis of
摘要：＜正＞ PK11195, a ligand of peripheral-type benzodiazepine receptor can stimulate thealdosterone secretion of isolated adrenal glomerulosa cell: this effect could be abolished by nifedipinewhich mainly blocks the calcium channel in plasma membrane, but could not be abolished bydantrolene, a selective blocker of mitochondria calcium channel. Even under the condition of themaximum stimulative effects on aldosterone secretion, PK11195 could not change the cyclic AMP（cAMP） content in isolated glomerulosa cells. These results indicated that in the modulatory mecha-nism of benzodiazepine receptor on aldosterone secretion, the intracellular messenger might be theCa2+ from extracellular Ca2+ pool, but not the Ca2+ from mitochondria Ca2+ pool or cAMP.
摘要：＜正＞ The correlation of secondary brain injury with thromboxane A2（TXA2） and prostacy-clin （PGI2） levels following head injury was studied in rats and patients.Thromboxane B2（TXB2） and 6-keto-PGF1α in rat brain homogenate and TXB2 in cerebral spinal fluid （CSF） ofpatients with severe head injury were determined by RIA.The effects of ligustrazini hydrochlo-rioi were also tested.The results showed that the concentration of TXB2 and 6-keto-PGF1α inrat brain was progressively increased within 3h after injury （P＜0.01）,and the ratio betweenTXB2 and 6-keto-PGF1α（T/K value） increased during the early stage after injury,along withthe tissue damage aggravation.After the use of ligustrazini hydrochlorioi,TXB2 content inbrain decreased sharply accompanied with a drop in T/K value.Moreover,TXB2 content inCSF increased within 7 d after injury （P＜0.01）,and it reached its peak value on the 3rd day.This could indicate that the metabolic imbalance between TXA2 and PGI2 might be one of theimportant factors in the development of secondary brain injury,and ligustrazini hydrochlorioiproved to have a protective effect on the brain tissue by normalizing the metabolism of TXA2and PGI2.In addition,the metabolic disorders of TXA2 in the brain tissue of head injured pa-tients have much to do with the outcome of the patients.
摘要：＜正＞ Anti-hepatoma monoclonal antibodies HAb8,HAb18 IgG and HAb18 F（ab’）2were labelled with[131I]according to chloramine T method.The labelling rate andradioactivity were 51% and 9.58×10~4Bq/mg,respectively.After administration of the[131I]-labelled conjugates through mouse tail vein,hepatoma xenografts were clearly im-aged,Localization index was 2.15,3.09,and 6.99 for HAb8,HAb18 IgG and HAb18F（ab’）2,respectively.A total of 16 hepatoma-bearing nude mice（SMMU-LTNM）were di-vided into 4 groups.When xenografts reached 0.3cm in diameter,the treatment was be-gun by injection of the[131I]-conjugates through mouse tail vein.After 2 weeks of treat-ment,obvious inhibitory or killing effects on the xenografts were found.The tu-mor-bearing mice were killed during the period from 14 to 21d after treatment.Xenografts as well as other organs were sampled and viewed under light microscope ac-cording to routine procedure.The vital organs,such as heart,liver,spleen,lung,kidneyand brain showed no pathological lesions.In hepatoma xenografts,some tumor cellmembranes were found,with obscure cytoplasmic structure and increased eosinophilia,representing necrotic alterations.
摘要：＜正＞Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.
摘要：＜正＞The Laerdal Company was established in 1940.During our first two decades,we created innovative toys and books for children.In 1958,the company started to dedicate itself to advancing the cause of resuscitation and emergency care.In I960,the first patient simulator Resusci Anne manikin was introduced to the market.Nowadays headquartered in Stavanger,Norway,Laerdal has gradually established sales operations in more than 20countries and manufacturing and R＆D operation units in 4 locations.The company has 1350 employees.Nowadays headquartered in Stavanger,Norway,Laerdal has gradually established sales operations in more than 20countries and manufacturing and R＆D operation units in 4 locations.The company has 1350 employees.
摘要：＜正＞The operating room is not only the heart of the surgical patient process.Despite its cost-and labourintensity it represents an important source of the hospital’s income.The operating team works hand in hand through a variety of parallel processes.They rely on an increasing number of medical devices and instruments.At Drager we have been developing and refining our technology for more than a century,
摘要：＜正＞Military Medical Research（MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R）,an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
摘要：＜正＞Call for papers Cancer Biology＆Therapy publishes original research on the molecular basis of cancer,including articles with translational relevance to diagnosis or therapy.In addition,Cancer Biology＆Therapy includes timely reviews,OP-ED pieces and meeting reports that lie within the broad scope of the journal and the expertise of the Editorial Board.The goal of Cancer Biology＆Therapy is to foster communication and rapid exchange of information through expedient
摘要：＜正＞Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.
摘要：＜正＞helping save The Laerdal Company was established in 1940.During our first two decades,we created innovative toys and books for children.In 1958,the company started to dedicate itself to advancing the cause of resuscitation and emergency care.In 1960,the first patient simulator Resusci Anne manikin was introduced to the market.Nowadays headquartered in Stavanger,Norway,Laerdal has gradually established sales operations in more than 20
摘要：＜正＞Military Medical Research（MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R）,an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
摘要：＜正＞In January of 2010 we will launch Bioengineered Bugs,the first international peerreviewed journal of its kind to focus on genetic engineering which involves the generation of recombinant strains（from higher plants and animals to bacteria,fungi and viruses）and their metabolic products for beneficial applications in food,medicine,industry,environment and bio-defense.
摘要：＜正＞Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.
摘要：＜正＞Call for papers Cancer Biology ＆ Therapy publishes original research on the molecular basis of cancer,including articles with translational relevance to diagnosis or therapy.In addition.Cancer Biology ＆ Therapy includes timely reviews,OP-ED pieces and meeting reports that lie within the broad scope of the Journal and the
摘要：The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and beyond. On August 8, 2014, the World Health Organization（WHO） declared the cross-country Ebola outbreak a Public Emergency of International Concern. China has had no confirmed cases of Ebola. In this paper, virologic characteristics, pathogenesis, clinical manifestations, laboratory examination and prophylactic vaccines and therapeutic drugs of Ebola are summarized. Importantly, active responses and actions from China are introduced. Moreover, the key issues in the future prevention and control of Ebola were also addressed.
摘要：Background: Chronic hepatitis is a major public health problem. The hepatitis B virus is the primary cause, and Hepatitis B and C together are responsible for 60% of cirrhosis and 80% of hepatocellular carcinomas. This study measured the prevalence of HBsAg among Senegalese military to develop a strategy to prevent cirrhosis and hepatocellular carcinoma in the army.Methods: We conducted a descriptive cross-sectional study among Senegalese army staff aged 25 to 60 years and divided this group into three strata: 25-34, 35-44 and 45-60 years. A sample of 1224 participants was selected following a two-level stratification. The mark of surface HBs antigen（Ag） was performed on 1195 participants using chemiluminescence（qualitative Architect HBsAg of Abbott Diagnostics Laboratories Germany） and enzyme immunoassay（Determines HBsAg） methods. The presence of HBsAg was analyzed according to age, marital status, alcohol consumption and glomerular filtration rate. Epi-info6 and R software were used, respectively, for data capture and analyses. A Chi-square test was performed to compare proportions considering an alpha significance level of 5% and a confidence interval of 95%.Results: The average age was 39.8±9.2 years. Participants in the age groups of 25-34 years, 45-60 years and 35-44 years were 30.7%, 34.4% and 34.9% of the sample, respectively. Married persons accounted for 82.6% of participants, and 17.08% were single. Most participants were educated（99%）, and 56% had reached at least the secondary school level. Alcohol consumption was at 11.5%. The HBsAg prevalence rate was 10.8% [9.1% to 12.7%] with a significant difference between age groups（P＜0.001）, which ranged from 5.6% for 45-60 years, 9.62% in the 25-34 years group and 16.9% for the 35-44 years group. Marital status and alcohol consumption did not affect the carriage of HBsAg. The prevalence of HBsAg was more common among participants who had a glomerular filtration rate greater than 90 ml/min. Transaminases rate exceeded the normal threshold in 43 participants（3.6%）. The increase was 6.6% [2.7% to 11.8%] of HBsAg carriers and 3.2% [1.2% to 6.7%] of alcohol users.Conclusion: The high prevalence of HBsAg in the military requires the implementation of an accessible prevention and care program to reduce the risk of cirrhosis and hepatocellular carcinoma. This program will contribute to reducing the burden of communicable diseases, such as hepatitis and HIV/AIDS, and non-communicable diseases in the armed forces.
摘要：The outbreak of Ebola virus disease（EVD） continues to spread through West Africa. Since the first reported EVD in March 2014, the number of cases has increased rapidly, with the fatality rate of ＞50%. The most prevalent Ebola virus belongs to the species of Zaire ebolavirus, with a mortality rate as high as 90%. Although there were introduced cases in other continents, Africa is the endemic area where fruit bats and apes are suspected to be Ebola virus carriers. The virus might be transmitted from the host animals to humans if humans consume relative raw and contaminated meats; however, human-to-human transmission via close contact is the major route of current outbreaks. EVD happens at any seasons and affected people of any race in any age groups. Direct contact with body fluids of EVD patients and living in the contaminated environment greatly increase the risk of being infected. Transmission viaaerosol is less possible but the transmission via droplet is possible in humans. Thus, health care providers are facing danger of getting Ebola virus infection. So far, there are limited vaccines, drugs and/or therapies to prevent Ebola virus infection or treat EVD. Medical workers should follow the current standard prophylactic procedures. Military forces can orchestrate efficient care to mass EVD casualties. Although it is necessary to speed up the pace of developing effective vaccine and therapeutics for the prevention and treatment of EVD, public health prophylaxis is the most important issue at present to control the spread of this disease cost-effectively.
摘要：The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack of normal immune homeostatic functions and excessive production of proinflammatory cytokines, which leads to multi-organ failure. The Toll-like receptor（TLR） family, one of whose members was initially discovered in Drosophila, performs an important role in the recognition of microbial pathogens. These pattern recognition receptors（PRRs）, upon sensing invading microorganisms, activate intracellular signal transduction pathways. NOD signaling is also involved in the recognition of bacteria and acts synergistically with the TLR family in initiating an efficient immune response for the eradication of invading microbial pathogens. TLRs and NOD1/NOD2 respond to different pathogenassociated molecular patterns（PAMPs）. Modulation of both TLR and NOD signaling is an area of research that has prompted much excitement and debate as a therapeutic strategy in the management of sepsis. Molecules targeting TLR and NOD signaling pathways exist but regrettably thus far none have proven efficacy from clinical trials.
摘要：Hearing plays a vital role in the performance of a soldier and is important for speech processing. Noise-induced hearing loss is a significant impairment in the military and can affect combat performance. Military personnel are constantly exposed to high levels of noise and it is not surprising that noise induced hearing loss and tinnitus remain the second most prevalent service-connected disabilities. Unfortunately, unlike civilian personnel, military personnel have little option but to remain in noisy environments in order to complete specific tasks and missions. Use of hearing protection devices and follow-up audiological tests have become the mainstay of prevention of noise-induced hearing loss. This review focuses on sources of noise within the military, pathophysiology and management of patients with noise induced hearing loss.
摘要：With the rapid development of electronic technologies, anxiety regarding the potential health hazards induced by microwave radiation（MW） has been growing in recent years. The brain is one of the most sensitive target organs for microwave radiation, where mitochondrial injury occurs earlier and more severely than in other organs. Energy metabolism disorders do play an important role during the process of microwave radiation-induced brain damage. In this paper, we will review the biological effects of microwave radiation, the features of brain energy supply and consumption and the effects of microwave radiation on mitochondrial energy metabolism and potential related mechanisms.
摘要：The Mesoamerican Ministers of Health have set 2020 as the target for malaria elimination to be achieved in the region. Imported malaria cases are a potential threat to countries attempting elimination or working to prevent resurgence. We report the first imported Plasmodium ovale infection with molecular confirmation in Central America, which occurred in a Guatemalan soldier that had been deployed in Africa. The obstacles for its diagnosis using the standard microscopy technique and the need to improve its detection are discussed.
摘要：＜正＞Overview Military Medical Research is an open access,peer-reviewed journal publishing cut ing-edge i ndings on basic medical science and important clinical research that is related to military medicine.Open access All articles published by Military Medical Research are made freely and permanently accessible online immediately upon publication,without subscription charges or registration barriers.Every peer-reviewed research article appearing in any journal published by Bio Med Central is’open access’,meaning that:
摘要：＜正＞Military Medical Research（MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R）,an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology
