An experimental and clinical study on TXA2 and PGI2 content after head injury

摘要

＜正＞ The correlation of secondary brain injury with thromboxane A2（TXA2） and prostacy-clin （PGI2） levels following head injury was studied in rats and patients.Thromboxane B2（TXB2） and 6-keto-PGF1α in rat brain homogenate and TXB2 in cerebral spinal fluid （CSF） ofpatients with severe head injury were determined by RIA.The effects of ligustrazini hydrochlo-rioi were also tested.The results showed that the concentration of TXB2 and 6-keto-PGF1α inrat brain was progressively increased within 3h after injury （P＜0.01）,and the ratio betweenTXB2 and 6-keto-PGF1α（T/K value） increased during the early stage after injury,along withthe tissue damage aggravation.After the use of ligustrazini hydrochlorioi,TXB2 content inbrain decreased sharply accompanied with a drop in T/K value.Moreover,TXB2 content inCSF increased within 7 d after injury （P＜0.01）,and it reached its peak value on the 3rd day.This could indicate that the metabolic imbalance between TXA2 and PGI2 might be one of theimportant factors in the development of secondary brain injury,and ligustrazini hydrochlorioiproved to have a protective effect on the brain tissue by normalizing the metabolism of TXA2and PGI2.In addition,the metabolic disorders of TXA2 in the brain tissue of head injured pa-tients have much to do with the outcome of the patients.