Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan

Muneki Hotomi; Dewan S. Billal; Yosuke Kamide; Keiko Kanesada; Yoshifumi Uno; Fumiyo Kudo; Masato Ito; Seiji Kakehata; Rinya Sugita; Masashi Ogami; Noboru Yamanaka

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Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan

机译：日本小儿急性中耳炎患者中耳液中肺炎链球菌分离株的血清型分布和青霉素耐药性

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Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan.

机译：从中耳液中分离出的175株肺炎球菌中，有26.3％是耐青霉素的 S。肺炎（PRSP）。血清型19F和23F在PRSP菌株中最常见。 7价肺炎球菌结合疫苗（PCV）显示PRPR菌株的覆盖率更高（87.0％）。在日本，七价PCV可能会降低PRSP的患病率。 展开▼

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《Journal of Clinical Microbiology》 |2008年第11期|共3页

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Muneki Hotomi; Dewan S. Billal; Yosuke Kamide; Keiko Kanesada; Yoshifumi Uno; Fumiyo Kudo; Masato Ito; Seiji Kakehata; Rinya Sugita; Masashi Ogami; Noboru Yamanaka;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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专利

1. Impact of the Seven-valent Pneumococcal Conjugate Vaccine on Acute Otitis Media in Japanese Children Emergence of Serotype 15A Multidrug-resistant Streptococcus pneumoniae in Middle Ear Fluid Isolates [J] . Ozawa Daiki, Yano Hisakazu, Endo Shiro, The Pediatric infectious disease journal . 2015,第9期

机译：七价肺炎球菌结合疫苗对日本儿童中耳分离液中血清型15A多重耐药肺炎链球菌的急性中耳炎的影响

2. Streptococcus pneumoniae Serotypes and Antibiotic Susceptibility Patterns in Middle Ear Fluid Isolates During Acute Otitis Media and Nasopharyngeal Isolates During Community-acquired Alveolar Pneumonia in Central Romania [J] . Lixandru Raluca-Ileana, Falup-Pecurariu Cristian, Bleotu Laura, The Pediatric infectious disease journal . 2017,第2期

机译：在罗马尼亚中部急性中耳炎培养基和鼻咽分离株期间，中耳液和鼻咽分离物中的中耳液和抗生素敏感模式在罗马尼亚州的肺炎肺炎

3. Streptococcus pneumoniae Isolates from Middle Ear Fluid and Nasopharynx of Children with Acute Otitis Media Exhibit Phase Variation [J] . Jun Arai, Muneki Hotomi, Susan K. Hollingshead, Journal of Clinical Microbiology . 2011,第4期

机译：急性中耳炎患儿中耳液和鼻咽中分离出的肺炎链球菌相变

4. A Double-blind Comparative Study of Tebipenem Pivoxil in Pediatric Patients with Acute Otitis Media [C] . Suzuki K., Baba S., Ubukata K., Extraordinary International Symposium on Recent Advances in Otitis Media . 2009

机译：急性中耳炎患者Tebipenem Pivoxil的双盲对比研究

5. Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan [D] . Oodate Mitsuru, 大舘満 2019

机译：在日本一些地区引入PCV7疫苗后，在青霉素-不敏感的肺炎链球菌中，血清素19 CC320 / 271占优势

6. Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan [O] . Muneki Hotomi, Dewan S. Billal, Yosuke Kamide, 2008

机译：日本小儿急性中耳炎患者中耳液中肺炎链球菌分离株的血清型分布和青霉素耐药性

7. Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan ▿ [O] . Hotomi, Muneki, Billal, Dewan S., Kamide, Yosuke, 2008

机译：日本小儿急性中耳炎患者中耳液中肺炎链球菌分离株的血清型分布和青霉素耐药性▿

8. Otitis Media with Effusion in Young Children. Clinical Practice Guideline Number12; Managing Otitis Media with Effusion in Young Children. Quick Reference Guide for Clinicians Number 12; Middle Ear Fluid in Young Children: Consumer Version. Clinical Pract [R] . 1994

机译：中耳炎患儿的中耳炎。临床实践指南第12号;青少年积液治疗中耳炎。第12号临床医生快速参考指南;幼儿中耳液：消费者版。临床实践

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2. 儿童急性中耳炎肺炎链球菌分离株的临床分布特点和药物敏感性分析 [J] . 郝丽丽 ,王智楠 ,张振 . 中国感染与化疗杂志 . 2016,第005期

3. 672株痰分离肺炎链球菌的年龄性别分布及对青霉素和左旋氧氟沙星的耐药性 [J] . 彭德胜 . 中国医师杂志 . 2014,第008期

4. 584株临床分离儿童痰液肺炎链球菌血清型／群分布研究 [J] . 李松涛 ,岳玉林 ,孙航 . 国际检验医学杂志 . 2014,第018期

5. 北京上海广州深圳4家儿童医院肺炎住院患儿肺炎链球菌分离株的血清型分布 [J] . 姚开虎 ,沈叙庄 ,杨永弘 . 中国循证儿科杂志 . 2008,第006期

6. 两种不同血清型肺炎链球菌致C57BL/6小鼠急性中耳炎的敏感性差异 [C] . 王维 ,周爱娥 ,黄益飞 . 中华医学会第十八次全国儿科学术会议 . 2013

7. 重庆儿童医院肺炎链球菌临床分离株耐药性与血清型研究 [A] . 张在亭 . 2006

1. 用针对肺炎链球菌血清型29进行保护的免疫原性组合物治疗患者的方法 [P] . 中国专利： CN114025784A . 2022-02-08

2. 阿莫西林和克拉维酸盐的组合物在生产抗耐药性肺炎链球菌的药物中的用途 [P] . 中国专利： CN1233958A . 1999-11-03

3. liquid composition for the treatment of pediatric otitis media, pediatric oral suspension, method of treatment for pediatric otitis media in patients under 24 months of age and method of treatment for haemophilus influenzae, and beta-lactamase-producing moraxella catarrhalis in pediatric patients with less than 24 months old [P] . 外国专利： BR112014016850A8 . 2017-07-04

机译：小于16岁的小儿中耳炎的液体组合物，小儿口服混悬液，24个月以下小儿中耳炎的治疗方法和流感嗜血杆菌的治疗方法以及产生β-内酰胺酶的卡他莫拉氏菌24个月大

4. liquid composition for the treatment of pediatric otitis media, pediatric oral suspension, method of treatment for pediatric otitis media in patients under 24 months of age and method of treatment for haemophilus influenzae, and beta-lactamase-producing moraxella catarrhalis in pediatric patients with less than 24 months old [P] . 外国专利： BR112014016850A2 . 2017-06-13

机译：小于16岁的小儿中耳炎的液体组合物，小儿口服混悬液，24个月以下小儿中耳炎的治疗方法和流感嗜血杆菌的治疗方法以及产生β-内酰胺酶的卡他莫拉氏菌24个月大

5. Liquid composition for the treatment of otitis media in children, pediatric oral suspension.Method of treatment of pediatric otitis media in patients with less than 24 months of age and method of treatment of Haemophilus influenzae.And Moraxella catarrhalis producing beta lactamase in pediatric patients aged less than 24 months of age. [P] . 外国专利： BR112014016850A8 . 2017-06-13

机译：用于治疗儿童中耳炎的液体组合物，儿科口服混悬液.24个月以下患者的中耳性中耳炎的治疗方法和流感嗜血杆菌的治疗方法和少发性儿科患者中的卡他莫拉菌产生β-内酰胺酶超过24个月大。

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Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan

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