无症状高尿酸血症对男性肾功能的影响

摘要

Objective To investigate the effects of asymptomatic hyperuricemia ( HUA ) on male kidney function . Methods 252 male patients with asymptomatic HUA ( HUA group ) and 157 healthy male cases with normal blood uric acid ( NUA group ) conducted a questionnaire survey , physical examination , serum creatinine ( Scr ) and urea nitrogen (BUN) were measured.Calculation of glomerular filtration rate (eGFR) according to MDRD, to compare renal function between two groups .Results Compared with NUA group , the eGFR was lower and Scr was higher in HUA group ( both P<0.05).There were significant differences in eGFR, Scr and BUN in different age groups in HUA group (eGFR: F=10.939, P=0.000;Scr:F=2.848, P=0.025;BUN:F=4.419, P=0.002).In NUA group, the eGFR in the 65-79 age cases was significantly lower than that of 21-30 age and 31-40 age cases (F=2.587, P=0.039);Scr and BUN were no significant differences in different age cases .The rate of declining renal function in HUA group was significantly higher than that in NUA group (P<0.05).Conclusions The risk of declining renal function in male asymptomatic hyperurice-mia patients increases with time-dependent manner .For asymptomatic hyperuricemia patients , it may be necessary to take effective measures to control the blood uric acid level to reduce its effect on renal function .%目的：探讨无症状高尿酸血症（ HUA）对男性肾功能的影响。方法男性无症状高尿酸血症患者252例（ HUA组），年龄与之匹配、血尿酸正常的男性健康体检者157例（ NUA组），进行问卷调查、体格检查及血肌酐（Scr）、尿素氮（ BUN）等生化指标检测，按 MDRD 方程估算肾小球滤过率（ eGFR），对比两组肾功能水平。结果 eGFR在HUA组低于NUA组，Scr在HUA组则高于NUA组（P均＜0．05），BUN在两组差异无统计学意义（P＞0．05）。在HUA组中，eGFR、Scr和BUN在不同年龄段中差异有统计学意义（eGFR：F＝10．939，P＝0．000；Scr：F＝2．848，P＝0．025；BUN：F＝4．419，P＝0．002）；NUA组中，eGFR在65～79岁年龄段显著低于21～30岁及31～40岁年龄段（eGFR：F＝2．587，P＝0．039），而Scr和BUN在不同年龄段中差异无统计学意义（P均＞0．05）。肾功能下降在HUA组的发生率高于NUA组（ P＜0．05）。结论男性无症状HUA患者发生肾功能下降的风险增加，且随着年龄的增长更明显；对于单纯无症状HUA患者，可能采取有效措施控制血尿酸水平以减少其对肾功能的影响。