Objective To observe the clinical effect of rosuvastatin calcium tablets combined with shuxuetong injection in treating elderly patients with acute cerebral infarction.Methods From 2015 to 2016,a total of 69 elderly patients with acute cerebral infarction were selected in the Health Clinic of Qilihe Sanatorium for Retired Cadres,Xiangyang Military Division,and they were divided into control group(n=34)and observation group(n=35)according to random number table. Based on conventional treatment,patients in control group received rosuvastatin calcium tablets,while patients in observation group received rosuvastatin calcium tablets combined with shuxuetong injection;both groups continuously treated for 6 months. Blood lipids index,inflammatory cytokines,CIMT,number of plaques,plaques area,NIHSS score before and after treatment were compared between the two groups,meanwhile prognosis and incidence of adverse reactions during the treatment were observed.Results No statistically significant differences of serum level of TG,TC,LDL-C or HDL-C was found between the two groups before treatment(P>0.05);after treatment,serum levels of TG,TC and LDL-C in observation group were statistically significantly lower than those in control group(P<0.05),while no statistically significant differences of serum HDL-C level was found between the two groups(P>0.05).No statistically significant differences of serum level of hs-CRP,IL-8 or TNF-α was found between the two groups(P>0.05),while serum levels of hs-CRP,IL-8 and TNF-α in observation group were statistically significantly lower than those in control group after treatment(P<0.05).No statistically significant differences of CIMT,number of plaques or plaques area was found between the two groups before treatment(P>0.05);after treatment,CIMT and plaques area in observation group were statistically significantly smaller than those in control group (P<0.05),while no statistically significant differences of number of plaques was found between the two groups(P>0.05). No statistically significant differences of NIHSS score was found between the two groups before treatment(P>0.05),while NIHSS score in observation group was statistically significantly lower than that in control group(P<0.05).The proportion of patients with good prognosis in observation group was statistically significantly higher than that in control group(P<0.05).No one in the two groups occurred serious adverse reactions,such as hepatic or renal insufficiency,emesis and anaphylaxis,a few patients occurred insomnia,abdominal distension,nausea and so on.Conclusion Rosuvastatin calcium tablets combined with shuxuetong injection has certain clinical effect in treating elderly patients with acute cerebral infarction,can effectively adjust the blood lipid metabolism,improve the neurological function and prognosis,relieve the inflammatory reaction and delay the progress of arteriosclerosis,with relatively high safety.%目的 观察瑞舒伐他汀钙片联合疏血通注射液治疗老年急性脑梗死的临床疗效.方法 选取2015—2016年湖北省襄阳军分区襄阳七里河离职干部休养所卫生所收治的老年急性脑梗死患者69例,采用随机数字表法分为对照组34例与观察组35例.在常规治疗基础上,对照组患者予以瑞舒伐他汀钙片治疗,观察组患者予以瑞舒伐他汀钙片联合疏血通注射液治疗;两组患者均连续治疗6个月.比较两组患者治疗前后血脂指标、炎性因子、颈动脉内中膜厚度(CIMT)、斑块数量、斑块面积、美国国立卫生研究院卒中量表(NIHSS)评分,观察两组患者预后情况及治疗期间不良反应发生情况.结果 治疗前两组患者血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清TG、TC、LDL-C水平低于对照组(P<0.05),两组患者血清HDL-C水平比较,差异无统计学意义(P>0.05).治疗前两组患者血清超敏C反应蛋白(hs-CRP)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清hs-CRP、IL-8、TNF-α水平低于对照组(P<0.05).治疗前两组患者CIMT、斑块数量、斑块面积比较,差异无统计学意义(P>0.05);治疗后观察组患者CIMT、斑块面积小于对照组(P<0.05),两组患者斑块数量比较,差异无统计学意义(P>0.05).治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者NIHSS评分低于对照组(P<0.05).观察组患者预后良好率高于对照组(P<0.05).两组患者治疗期间均未发生肝肾功能不全、呕吐、过敏等严重不良反应,仅少数患者发生失眠、腹胀、恶心等.结论 瑞舒伐他汀钙片联合疏血通注射液治疗老年急性脑梗死的临床疗效确切,可有效改善患者血脂代谢、神经功能和预后,减轻炎性反应并延缓动脉粥样硬化进展,且安全性较高.
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