不同大鼠模型探讨连翘挥发油解热、抗炎作用

摘要

To investigate the effects of volatile oil of Forsythia suspense (VOFF) on different rat models,and explore the mechanism of its anti-inflammatory and antipyretic effects.Two rat fever models were established by subcutaneously injection of dry yeast and intraperitoneal injection of lipopolysaccharide (LPS) to evaluate the antipyretic effect of VOFF,respectively.Rats cotton ball granuloma model,rats foot swelling model induced by subcutaneous injection of carrageen or fresh egg white at the right posterior foot were used to evaluate the anti-inflammatory effects.VOFF can significantly inhibit LPS and dry yeast induced fever,reduce carrageenan and fresh egg white induced rat paw edema,compared with the model group (P ＜ 0.05).It can also significantly inhibit the proliferation of granulation tissue,compared with the model group (P ＜0.01).The results showed that VOFF had obvious antipyretic and anti-inflammatory effects,which provided a theoretical basis for further research on heat clearing and detoxifying function.%观察连翘挥发油对不同大鼠模型的作用,探讨其解热、抗炎的作用机理.采用干酵母皮下注射和脂多糖腹腔注射建立大鼠发热模型评价连翘挥发油的解热作用,采用右后足皮下注射角叉菜胶、鸡蛋清建立大鼠足肿胀模型以及建立大鼠棉球肉芽肿模型评价其的抗炎作用.发现连翘挥发油可抑制脂多糖和干酵母所致发热,降低角叉菜胶和鸡蛋清所诱导的大鼠足肿胀,与模型组对比均有明显差异(P＜0.05);且可显著抑制肉芽组织的增生,与模型组对比有明显差异(P＜0.01).结果表明连翘挥发油具有明显的解热、抗炎作用,为对其清热解毒作用作进一步的研究提供了一定的理论依据.